Luke O'Neill (Trinity College, Ireland)
“Fine -tuning TLR and NLR signaling”
Shizuo Akira (Osaka University, Japan)
“Roles of TLR inducible genes revealed by gene targeting”
Jie-Oh Lee (Korea Advanced Institute of Science and Technology)
“Crystal structures of the TLR-ligand complexes”
Ruslan Medzhitov (Yale University School of Medicine, USA)
“Innate Control of Adaptive Immunity”
Jürg Tschopp (University of Lausanne, Switzerland)
“The inflammasomes”
Tadatsugu Taniguchi (University of Tokyo, Japan)
“Nucleic acid sensing and activation of immune responses”
Gordon Brown (University of Aberdeen, UK)
“Anti-fungal immunity”
Caetano Reis e Sousa (London Research Institute, UK)
“Innate regulation of adaptive immunity by dendritic cells”
Lewis Lanier (UCSF, USA)
“NK cells in viral immunity”
Adrian Hayday (King's College London, UK)
“Molecular mechanisms mediating the lymphoid stress-surveillance response”
Shigeo Koyasu (Keio University School of Medicine, Japan)
“Natural helper cell: a newly identified innate lymphocyte producing Th2 cytokines”
Marco Colonna (Washington University School of Medicine, USA)
To be announced
Takashi Fujita (Kyoto University, Japan)
“Regulation of the innate antiviral response by local condensation of IPS-1 mediated by mitochondrial dynamism”
Zhijian Chen (University of Texas at Dallas, USA)
“Biochemical dissection of antiviral signaling cascades”
Christine Biron (Brown University, USA)
“Communication between innate and adaptive immune responses to viral infections”
Wayne Yokoyama (Washington University School of Medicine, USA)
“Immune evasion of innate and adaptive immunity”
Stipan Jonjic (University of Rijeka, Croatia)
“Cytomegalovirus protein m04 abolishes NK cell activation via the “missing-self” recognition mechanism”
Akiko Iwasaki (Yale University School of Medicine, USA)
“Mucosal antiviral immunity”
Chihiro Sasakawa (University of Tokyo, Japan)
“Shigella circumvention of intestinal innate defense system”
Jenny Ting (University of North Carolina at Chapel Hill, USA)
“The NLR family in infection and immunity”
Alberto Mantovani (Istituto Clinico Humanitas and University of Milan, Italy)
“Humoral innte immunity as an integrated system:pentraxins as paradigm”
Yoichiro Iwakura (University of Tokyo, Japan)
“The roles of IL-17A/F in inflammation and host defense against infection”
Mitchell Kronenberg (La Jolla Institute for Allergy and Immunology, USA)
“Innate-like recognition of microbes by invariant natural killer T cells”
Arturo Zychlinsky (Max Planck Institute for Infection Biology, Germany)
“Neutrophil extracellular traps in infection and autoimmunity”
Adrian Hill (University of Oxford, UK)
“New vaccination approaches for malaria”
Paul Kaye (University of York, UK)
“Immune regulation in the Leishmania granuloma: Macrophages, T cells and more⋯.”
Alan Sher (National Institute of Allergy and Infectious Diseases, USA)
“Initiating and polarizing functions of dendritic cells in the immune response to parasites”
Kenji Nakanishi (Hyogo College of Medicine, Japan)
“Innate and acquired immunity in expulsion of intestinal nematode”
Thomas Wynn (National Institute of Health, USA)
“Role of Arginase-1 in suppressor macrophage activity revealed with cell-specific knockout mice”
Maria Yazdanbakhsh (Leiden University Medical Center, Netherlands)
“Modulation of the immune system by parasitic helminthes:how, why and so what?”
Shimon Sakaguchi (Kyoto University, Japan)
“Regulatory T cells for self-tolerance”
Ethan Shevach (National Institute of Allergy and Infectious Diseases, USA)
“Control of immune responses by natural and adaptive T regulatory cells”
Alexander Rudensky (Memorial Sloan Kettering and Howard Hughes Medical Institute, USA)
“Molecular determinants of differentiation and function of regulatory T cells”
Daniel Cua (Schering-Plough Biopharma, USA)
“Cytokine regulation of autoimmunity:targeting the Th17 immune pathway”
Vijay Kuchroo (Harvard Medical School, USA)
“Interplay between T-regs and Th17 cells”
Dan Littman (New York University School of Medicine, USA)
“Transcription factor networks in Th17 cell differentiation”
Diane Mathis (Harvard Medical School, USA)
“Molecules and cells controllling autoimmunity”
Abul Abbas (University of California, San Francisco, USA)
“T-cell tolerance and autoimmunity”
Luciano Adorini (Intercept Pharmaceuticals, Italy)
“Control of autoimmune diseases by the vitamin D system and other nuclear receptor agonists”
Shigekazu Nagata (Kyoto University, Japan)
“Engulfment and degradation of dead cells”
Reinhold Schmidt (Medizinische Hochschule Hannover, Germany)
“Antibody-mediated inflammatory processes”
Betty Diamond (Feinstein Institute for Medical Research, USA)
“Neuropsychiatric disese and antibodies”
Maria Rescigno (European Institute of Oncology, Italy)
“Dendritic cells in bacterial handling in the gut”
Yasmine Belkaid (National Institute of Allergy and Infectious Diseases, USA)
“Control of regulatory T cells by microbes”
Sidonia Fagarasan (RIKEN, Research Center for Allergy and Immunology, Japan)
“Adaptive immune regulation in the gut:T cell-dependent and T cell-independent IgA synthesis”
Fiona Powrie (University of Oxford, UK)
To be announced
David Artis (University of Pennsylvania, USA)
“Regulation of immunity and inflammation in the gut”
Richard Blumberg (Harvard Medical School, USA)
“Endoplasmic Reiculum Stress and Intestinal Inflammation”
Ludger Klein (Ludwig-Maximilians-University, Germany)
“Autonomous role of medullary thymic epithelial cells in central CD4 T cell tolerance”
Mitsuru Matsumoto (University of Tokushima, Japan)
“Roles of thymic epithelial cells for the establishment of self-tolerance”
Christopher Goodnow (Australian National University, Australia)
“Multi-step breakdown of tolerance in autoimmunity”
David Wraith (University of Bristol, UK)
“Negative feedback mechanisms in peripheral tolerance”
Kathryn Wood (John Radcliffe Hospital, UK)
“Controlling rejection - a role of Treg and MSC”
Herman Waldmann (University of Oxford, UK)
“Mechanisms underlying infectioustolerance”
Robert Schreiber (Washington University School of Medicine, USA)
“Cancer Immunoediting: Basic mechanisms and therapeutic implications”
David Raulet (University of California Berkeley, USA)
“Regulation of NK cell responses to tumors and normal tissues”
Eric Vivier (Marseille University, France)
“Regulation of natural killer cell function”
Michael Karin (University of California, San Diego, USA)
“Innate responses to injury and death as promoters of tumor progression and metastasis”
Dmitry Gabrilovich (H. Lee Moffitt Cancer Center, USA)
“Lipid accumulation and dendritic cell dysfunction in cancer”
Laurence Zitvogel (Institute Gustave Roussy, France)
“Molecular bases of the immunogenicity of cell death in cancer”
Ana Cumano (Pasteur Institute, France)
“Lymphopoiesis during embryonic development”
Hans-Reimer Rodewald (German Cancer Research Center, Germany)
“Fate mapping of early T-cell development”
Avinash Bhandoola (University of Pennsylvania, USA)
To be announced
Yousuke Takahama (University of Tokushima, Japan)
“Thymic microenvironments that shape T cell repertoire”
Ichiro Taniuchi (RIKEN, Research Center for Allergy and Immunology, Japan)
“Transcriptional control of helper versus cytotoxic lineage choice”
Paul Kincade (Oklahoma Medical Research Foudation, USA)
“Functional Diversity of Stem and Progenitor Cells”
Miriam Merad (Mount Sinai School of Medicine, USA)
“Functional Diversity of non lymphoid tissue DCs”
Ulrich von Andrian (Harvard Medical School, USA)
“Visualizing the immune response”
Ellen Robey (University of California Berkeley, USA)
“Visualizing Thymic Selection in situ”
Jason Cyster (UCSF, USA)
“Cell position control and humoral immunity”
Masayuki Miyasaka (Osaka University, Japan)
“How does a lipid mediator-generating enzyme, autotoxin, regulate lymphocyte trafficking across high endothelial venules?”
Takashi Nagasawa (Kyoto University, Japan)
“The chemokine CXCL12 and niches for hematopoietic stem cells and immune cells”
Kristin Hogquist (University of Minnesota, USA)
“PLZF+ cells regulate the development of innate-like CD8 T cells through IL-4”
Marc Jenkins (University of Minnesota, USA)
“Determinants of naïve CD4+ T cell population size”
Michael McHeyzer-Williams (The Scripps Research Institute. USA)
“Follicular Helper T Cell Regulated B Cell Immunity”
David Nemazee (The Scripps Research Institute, USA )
““Missing self” recognition by B cells”
Michel Nussenzweig (The Rockefeller University, USA)
“Antibody diversity and lymphoma”
Frederick Alt (Children's Hospital Boston, USA)
“Mechanisms of CSR and translocations”
Rafi Ahmed (Emory University, USA)
“Memory T cell differentiation”
Michael Bevan (University of Washington, USA)
“Cytotoxic T cell differentiation”
Stephen Schoenberger (La Jolla Institute for Allergy and Immunology, USA)
“Molecular regulation of T help for CTL”
Federica Sallusto (Institute for Research in Biomedicine, Switzerland)
“Human memory T cells”
Andreas Radbruch (Deutsches Rheuma-Forschungszentrum, Germany)
“Organisation of immunological memory by bone marrow stromal cells”
Mark Shlomchik (Yale University School of Medicine, USA)
“Signaling, Survival and Differentiation in the Germinal Center”
John O'Shea (NIAMS, NIH, USA)
“Transcriptional and epigenetic control of helper T cell differentiation”
Anne O'Garra (The MRC National Institute for Medical Research, UK)
“Regulation of IL-10 production by cells of the innate and adaptive immune response and implications for immune response to pathogens”
Frederic Geissmann (Centre for Molecular and Cellular Biology of Inflammation, UK)
“differentiation and functions of 'mononuclear phagocytes' in vivo”
Antonio Celada (Institute for Research in Biomedicine, Spain)
“Macrophages and inflammation:mechanisms of survival”
Xuetao Cao (Second Military Medical University, China)
“Cross regulation of TLR-triggered pro-inflammatory cytokine production”
Toshio Hirano (Osaka University, Japan)
“Role of interleukin 6 amplifier in autoimmune diseases and inflammation”
Garry Nolan (Stanford University, USA)
“Single cell systems network analysis of autoimmune dysregulation”
Tomohiro Kurosaki (Osaka University and RIKEN Research Center for Allergy and Immunology, Japan)
“Store-operated Calcium Entry in B cells”
André Veillette (Clinical Research Institute of Motreal, Canada)
“SAP family adaptors in lymphocyte activation”
Arthur Weiss (University of California, San Francisco, USA)
“Regulation of tyrosine phosphorylation by the T cell antigen receptor”
Doreen Cantrell (University of Dundee, UK)
“Serine Kinases in T lymphocytes”
Pamela Schwartzberg (National Human Genome Institute, NIH, USA)
“Integrating T cell signals and effector cell function”
Sebastian Amigorena (Institut Curie, France)
“Antigen cross presentation in dendritic cells”
Hidde Ploegh (Whitehead Institute for Biomedicl Research, USA)
“Transnuclear mice made by somatic cell nuclear transfer from B and T lymphocytes”
Christian Münz (University of Zürich, Switzerland)
“Viral regulation of macroautophagic antigen processing for MHC presentation”
Bernard Malissen (Centre d'Immunologie de Marseille-Luminy, France)
“Disentangling the complexity of the dendrtitic cell network present in the skin”
William Heath (The University of Melbourne, Australia)
“Dendritic cell subsets involved in the initiation of CD8 T cell immunity to virus infection”
Michael Dustin (New York University School of Medicine, USA)
“Protein kinase C-θ mediates negative feedback on regulatory T cell function”
Ronald Germain (National Institute of Allergy and Infectious Diseases, NIH, USA)
“In situ dynamics of T cell co-operation and effector activation analyzed by 2 photon microscopy”
Takashi Saito (RIKEN Research Center for Allergy and Immunology, Japan)
“Spatio-temporal regulation of T cell activation”
Mark Davis (Stanford University School of Medicine, USA)
“T cell recognition and repertoire selection”
Susan Pierce (National Institute of Allergy and Infectious Diseases, NIH, USA)
“The molecular basis of the initiation of B cell receptor signaling”
Facundo Batista (London Research Institute, UK)
“Early events in B cell activation and initiation of immune response”
Anjana Rao (Harvard Medical School, USA)
“Structure of a domain-swapped FOXP3 dimer on DNA and its function in regulatory T cells”
Richard Flavell (Yale University School of Medicine, USA)
“Regulation of immune response at the molecular level”
Cornelis Murre (University of California San Diego, USA)
“Regulatory Network that Orchestrates B cell development”
Ellen Rothenberg (California Institute of Technology, USA)
“Transcriptional regulation of T cell specification and commitment”
Stephen Nutt (The Walter and Eliza Hall Institute, Australia)
“The Transcriptional Regulation of Lymphocyte and Dendritic Cell Differentiation”
Kenneth Murphy (Washington University School of Medicine, USA)
“BATF family AP-1 transcription factors regulate immune lineage decisions”
Hitoshi Kikutani (Osaka University, Japan)
“Semaphorins in immune cell communication”
Carl Ware (La Jolla Institute for Allergy and Immunology, USA)
“The LIGHT-HVEM-BTLA consignaling in immune activation and viral evasion”
Arlene Sharpe (Harvard Medical School, USA)
“Roles of PD-1 and PD-L1 in regulating the balance between T cell activation and tolerance”
Christopher Rudd (University of Cambridge, UK)
“Coreceptor signalling and regulation of adaptive immunity”
Chen Dong (University of Texas, USA)
“Costimulation-dependent regulation of T cell tolerance and differentiation”
Carola Vinuesa (Australian National University, Australia)
“Sorting through the heterogeneity of T follicular helper cells”
Jacque Banchereau (Baylor Institute for Immunology Research, USA)
“Dendritic cell based vaccines”
Antonio Uccelli (University of Genova, Italy)
“Mesenchymal stem cells: a new cell therapy for autoimmune diseases”
Philip Greenberg (University of Washington, USA)
“Overcoming obstacles to effective T cell therapy of malignant disease”
Samuel Strober (Stanford University School of Medicine, USA)
“Natural killer T cells, Treg cells, and their interactions after bone marrow transplantation”
Lorenzo Moretta (Instituto Giannina Gaslini, Italy)
“Natural killer cells in the therapy of high-risk leukemias”
Masaru Taniguchi (RIKEN Research Center for Allergy and Immunology, Japan)
“NKT cell-targeted adjuvant cell therapy-from basic to clinic”
Jeffrey Ravetch (The Rockefeller University, USA)
“The antibody paradox: novel roles for Fc glycans”
James Allison (Memorial Sloan Kettering Cancer Center, USA)
“Immune checkpoint blockade in cancer therapy : new insights and opportunities”
Patrick Baeuerle (Micromet AG, Germany)
“T cell-engaging antibodies for cancer therapy”
Ronald Levy (Stanford University, USA)
“Antibody therapy of cancer, targeting the tumor and the host immune system”
Thomas Waldmann (National Cancer Institute,NIH, USA)
“Cytokine receptor directed monoclonal antibody mediated therapy of leukemia, Hodgkin's lymphoma and autoimmune diseases”
Marc Feldmann (Kennedy Institute of Rheumatology Division, UK)
“Anti TNF therapy : Why does it work and what comes next?”
Rino Rappuoli (Novartis Vaccines and Diagnostics, Italy)
To be announced
Glen N. Barber (University of Miami School of Medicine, USA)
“Intracellular DNA signaling pathways and the regulation of innate and adaptive immunity”
Bali Pulendran (Emory Vaccine Center, USA)
“Modulating vaccine responses with innate immunity”
Bing Sun (Chinese Academy of Sciences, China)
“Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling”
Peter Ernst (University of Virginia, USA)
“Challenges in stimulating mucosal immunity to luminal pathogens: What we have learned from Helicobacter pylori”
Hiroshi Kiyono (The University of Tokyo, Japan)
“Mucosal Immunity for new generation of needl/syringe-and cold chain- free vaccine”
Stephen Galli (Stanford University School of Medicine, USA)
“Mast cells as positive and negative regulators of innate and acquired immunity”
Hajime Karasuyama (Tokyo Medical and Dental University Graduate School, Japan)
“Novel roles for basophils in allergy and immunity”
Yong-Jun Liu (The University of Texas, USA)
“TSLP leads the TH2 pathway to allergic inflammation”
Bart Lambrecht (University Ghent, Belgium)
To be announced
Rudolf Valenta (Medical University of Vienna, Austria)
“Vaccination against allergy”
Cezmi Akdis (Swiss Institute of Allergy and Asthma Research, Switzerland)
“Mechanisms of immune tolerance to allergens”
Markus Manz (University Hospital Zurich, Switzerland)
“Translation of pathogen signals into enhanced production of innate immune effector cells”
Riitta Lahesmaa (University of Turku, Finland)
“Molecular mechanisms of human T helper cell differentiation”
Hergen Spits (University of Amsterdam, The Netherlands)
“B cell responses in human immune system(HIS) mice”
Kazuhiko Yamamoto (The University of Tokyo, Japan)
“Immune responses in rheumatoid arthritis”
Markus Heim (University Hospital Basel, Switzerland)
“Interferon signaling in viral hepatitis”
Alain Fischer (Hospital Necker, France)
“Molecular defects of T cell immunity in humans”
David Hafler (Yale School of Medicine, USA)
“The genetics of multiple sclerosis”
Takehiko Sasazuki (Kyusyu University, Japan)
“Immunogenetic risk factors for autoimmune thyroid disease and a novel transcriptional regulator ZFAT”
Judy Cho (Yale School of Medicine, USA)
“Genetics of autoimmunity”
Lars Klareskog (Karolinska Institute, Sweden)
“Genes, environment and immunity in rheumatoid arthritis”
Timothy Behrens (Genentech, USA)
“Genetics of SLE”
John D. Rioux (University of Montreal, Canada)
To be announced
Kiyoshi Takeda (Osaka University, Japan)
“Regulation of innate immune responses at the intestinal mucosa”
Takashi Yamamura (National Institute of Neuroscience, NCNP, Japan)
“Invariant T cells as sensors and regulators of commensal flora”
Marie Wahren-Herlenius (Karolinska Institute, Sweden)
“Ro52 in regulation of TLR signaling and induction of tissue inflammation”
Alexander Chervonsky (University of Chicago, USA)
“Commensal microbes and autoimmunity”
Howard Weiner (Harvard Medical School, USA)
“Induction of regulatory T cells by mucosal administration of aryl hydrocarbon receptor ligands and anti-CD3 monoclonal antibody in animals and humans”
Hilde Cheroutre (La Jolla Institute for Allergy and Immunology, USA)
“Operating with a fake ID at the border: Lineage switch of mucosal CD4T cells”
Jochen Huehn (Helmholtz-Centre for Infection Research, Germany)
“Epigenetic control of Foxp3 expression: the key to a stable Treg lineage?”
Shohei Hori (RIKEN Research Center for Allergy and Immunology, Japan)
“Stability and plasticity in regulatory Tcell differentiation”
Steve Ziegler ( Benaroya Research Institute, USA)
To be announced
Lucienne Chatenoud (Hôpital Necker-Enfants Malades, France)
“The challenge of immune tolerance induction in primed hosts”
Matthias Edinger (Klinikum der Universität Regensburg, Germany)
“Adoptive Treg cell transfer in allogeneic stem cell transplantation”
Maria-Grazia Roncarolo (San Raffaele Scientific Institute, Italy)
“Induction and function of antigen-specific type 1 regulatory T (Tr1) cells.”
Ann Marshak-Rothstein (University of Massachusetts, USA)
“Activation and Inhibition of Autoreactive B cells”
Bana Jabri (University of Chicago, USA)
“Interplay between adaptive and innate immunity in celiac disease”
Hartmut Wekerle (Max Planck Institute of Neurobiology, Germany)
“Completing a Jigsaw Puzzle: Experimental Studies of the Immune Pathogenesis of Multiple Sclerosis”
Sander van Deventer (Leiden University Medical Center, The Netherlands)
“Treatment of immune -mediated inflammatory disease: past and future”
Pierre Miossec (University of Lyon, France)
“IL-17 family members: contribution to joint inflammation and destruction”
Josef Smolen (Medical University of Vienna, Austria)
“Novel pathogenetic and therapeutic insights in rheumatoid arthritis”
Gabriel Nunez (University of Michigan)
“Function of NLRs in innate immunity and disease”
Eric Meffre (Yale University School of Medicine, USA)
“Human B-cell tolerance checkpoints in health and autoimmunity”
Frank Nestle (Guy's Hospital, UK)
“Skin inflammation: from genes to function and targeted therapy”
Virginia Pascual (Baylor Institute for Immunology Research, USA)
“A genomic approach to understand human autoimmune diseases”
Kouji Matsushima (University of Tokyo, Japan)
“Chemokines as therapeutic targets of inflammatory diseases and cancer”
Edward Wakeland (UT Southwestern Medical Center at Dalls, USA)
“Genomic analysis of susceptibility to SLE in humans”